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Pharmacology: Pharmacodynamics: Isotretinoin reduces sebaceous gland size and reduces sebum production; regulates cell proliferation and differentiation.
Pharmacokinetics: Distribution: Crosses placenta.
Protein binding: 99% to 100% primary albumin.
Metabolism: Hepatic via CYP2B6, 2C8, 2C9, 2D6, 3A4; forms metabolites; major metabolite: 4-oxo-isotretinoin (active).
Half-life elimination: Terminal: Parent drug: 21 hours; Metabolite: 21-24 hours.
Time to peak, serum: 3-5 hours.
Excretion: Urine and feces (equal amounts).
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