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Recommended dose: Children 12 - 17 years and adults: Severe recalcitrant nodular acne: 0.5 - 1 mg/kg/day in 2 divided doses for 15 - 20 weeks or until the total cyst count decreases by 70%, whichever is sooner.
Adults with very severe disease/scarring or primarily involves the trunk may require dosage adjustment up to 2 mg/kg/day. A second course of therapy may be initiated after a period of ≥ 2 months off therapy.
Dosing adjustment in hepatic impairment: Dose reductions empirically are recommended in hepatitis disease.
Mode of Administration: Administer with food.
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