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Avoid concomitant use: Tetracycline derivatives, Vitamin A.
Increased effect/Toxicity: Isotretinoin may increase the levels/effects of: Vitamin A.
The levels/effects of isotretinoin may be increased by: Ethyl alcohol, Tetracycline derivatives.
Decreased effect: Isotretinoin may decrease the levels/effects of: Contraceptives (Estrogens), Contraceptives (Progestins).
Ethanol/Nutrition/Herb interactions: Ethanol: Avoid or limit ethanol (may increase triglyceride levels if taken in excess).
Food: Isotretinoin bioavailability increased if taken with food or milk.
Herb/Neutraceuticals: Avoid Dong Quai, St. John's wort (may also cause photosensitization and may decrease the effectiveness of oral contraceptives). Additional vitamin A supplements may lead to vitamin A toxicity (dry skin, irritation, arthralgia, myalgia, abdominal pain, hepatic changes); avoid using it with isotretinoin.
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