Avoid concomitant use: Acemetacin, aminolevulinic acid (systemic), aspirin, dexibuprofen, dexketoprofen, floctafenine, ketorolac (nasal), macimorelin, mifamurtide, morniflumate, NSAIDs, omacetaxine, pelubiprofen, pentoxifylline, phenylbutazone, probenecid, talniflumate, tenoxicam, urokinase, zaltoprofen.
Increased effect/toxicity: Ketorolac may increase the effects of: 5-aminosalicylic acid derivatives, agents with antiplatelet properties, aliskiren, aminoglycosides, aminolevulinic acid (systemic and topical), anticoagulants, apixaban, aspirin, bemiparin, bisphosphonate derivatives, cephalothin, collagenase (systemic), cyclosporine (systemic), dabigatran etexilate, deferasirox, deoxycholic acid, desmopressin, dexibuprofen, digoxin, drospirenone, edoxaban, enoxaparin, eplerenone, haloperidol, heparin, ibritumomab, tiuxetan, lithium, metformin, methotrexate, neuromuscular-blocking agents (nondepolarizing), NSAID, obinutuzumab, omacetaxine, pentoxifylline, porfimer, potassium-sparing diuretics, pralatrexate, quinolones, rivaroxaban, salicylates, tacrolimus (systemic), tenofovir products, thrombolytic agents, tolperisone, urokinase, vancomycin, verteporfin, vitamin K antagonists.
The effects of ketorolac may be increased by: Acalabrutinib, acemetacin, alcohol (ethyl), angiotensin II receptor blockers, ACE inhibitors, corticosteroids (systemic), cyclosporine (systemic), desatinib, dexketoprofen, fat emulsion (fish oil based), felbinac, floctafenine, glucosamine, herbs (anticoagulants/antiplatelet properties), ibrutinib, inotersen, ketorolac (nasal), limaprost, loop diuretics, morniflumate, multivitamins/fluoride (with ADE), multivitamins/minerals (with ADEK, folate, iron, with AE, no iron), naftazone, omega-3 fatty acids, pelubiprofen, pentosan polysulfate sodium, phenylbutazone, probenecid, prostacyclin analogues, selective serotonin reuptake inhibitors, serotonin/norepinephrine reuptake inhibitors, sodium phosphates, talniflumate, tenoxicam, thiazide and thiazide-like diuretics, tipranavir, tolperisone, tricyclic antidepressants (tertiary amine), vitamin E (systemic), zaltoprofen, zanubrutinib.
Decrease Effect: Ketorolac may decrease the effects of: Aliskiren, angiotensin II receptor blockers, ACE inhibitors, aspirin, beta-blockers, eplerenone, hydralazine, loop diuretics, prostaglandins (ophthalmic), salicylates, selective serotonin reuptake inhibitors, sincalide, thiazide and thiazide-like diuretics.
The effects of Ketorolac may be decreased by: Bile acid sequestrants, salicylates.
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