Remopain 3% Contraindications

Ketorolac is contraindicated in patients with previously demonstrated hypersensitivity to ketorolac, any of its excipients or other NSAIDs and patients in whom aspirin or other prostaglandin synthesis inhibitors induce allergic reactions (severe anaphylactic-like reactions have been observed in such patients). Such reactions have included asthma, rhinitis, angioedema, or urticaria.
Ketorolac is also contraindicated in those with a history of asthma.
Ketorolac is contraindicated in patients with active or a history of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy. Active or history of recurrent peptic ulcer/hemorrhage (two or more distinct episodes of proven ulceration or bleeding).
As with other NSAIDs, ketorolac is contraindicated in patients with severe heart failure, hepatic failure, and renal failure.
Ketorolac is contraindicated in patients with moderate or severe renal impairment (serum creatinine >160 mcmol/l) or in patients at risk for renal failure due to volume depletion or dehydration.
Ketorolac is contraindicated as prophylactic analgesia before surgery due to inhibition of platelet aggregation and is contraindicated intraoperatively because of the increased risk of bleeding.
Ketorolac inhibits platelet function and is, therefore, contraindicated in patients with suspected or confirmed cerebrovascular bleeding, patients who have had operations with a high risk of hemorrhage or incomplete hemostasis and those at high risk of bleeding such as those with hemorrhagic diatheses, including coagulation disorders.
It is also contraindicated in patients on anticoagulants, including warfarin and low dose heparin (2,500-5,000 units 12 hourly).
Ketorolac is contraindicated in patients currently receiving acetylsalicylic acid (ASA) or other NSAIDs (including cyclooxygenase-2 selective inhibitors).
Ketorolac solution for injection is contraindicated for neuraxial (epidural or intrathecal) administration due to its alcohol content.
The combination of ketorolac with pentoxifylline is contraindicated. Concurrent treatment with ketorolac and probenecid or lithium salts is contraindicated.
Ketorolac is contraindicated in patients with the complete or partial syndrome of nasal polyps, angioedema, or bronchospasm.
Use in Pregnancy & Lactation: Ketorolac is contraindicated in pregnancy, labor, delivery, or lactation.