Pregalin Overdosage

Overdose and treatment: Overdose effects are expected to be extensions of adverse effects at therapeutic doses. In patients receiving greater than or equal to 900 mg, the clinical events reported were similar to those at the recommended doses. An adult ingested an estimated 1.5 g; mild drowsiness was the only symptom observed. An adult intentionally ingested 8.4 g of pregabalin and developed CNS depression and coma approximately 3 hours after exposure. The patient required intubation and mechanical ventilation for 26 hours. No permanent sequelae occurred. Treatment of pregabalin exposure is largely supportive in nature with careful attention to airway protection in severe cases. Consider activated charcoal if ingestion was recent. Hypotension is usually mild responding to intravenous fluid boluses. If hypotension persists, administer dopamine or norepinephrine. Admit all severely symptomatic patients. Treat seizures with IV benzodiazepines or barbiturates. Hemodialysis might be useful in patients with severe toxicity or those with significant renal impairment. Standard hemodialysis results in pregabalin clearance of approximately 50% in 4 hours. Dialysis is rarely necessary as most patients do well with supportive care.