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Drugs that may interact with pregabalin include ACE inhibitors, CNS depressants (e.g., lorazepam, ethanol, oxycodone), and thiazolidinediones.
Angiotensin-converting Enzyme Inhibitors: Potential pharmacologic interaction with angiotensin-converting enzyme (ACE) inhibitors (e.g., increased risk of developing angioedema).
CNS depressants: Potential pharmacologic interaction (e.g., additive CNS depressant effects) with concurrent administration of CNS depressants, including opiates and benzodiazepines.
Lorazepam, Ethanol, Oxycodone: Pharmacokinetic interaction unlikely. Potential pharmacologic interaction (e.g., additive effects on cognitive and gross motor functioning); no clinically important effects on respiration.
Thiazolidinediones: Potential pharmacologic interaction with thiazolidinediones (e.g., increased risk of weight gain and peripheral edema.
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