Pregalin Dosage/Direction for Use

Recommended Dose: Pregabalin is given orally in 2 or 3 divided doses daily.
For neuropathic pain the initial dose is 150 mg daily increased after 3 to 7 days according to response to 300 mg daily and then to 600 mg daily after another 7 days. Similar doses are used for the treatment of neuropathic pain in diabetic neuropathy postherpetic neuralgia, and spinal cord injury, although a maximum daily dose of 300 mg is recommended in diabetic neuropathy because dosages up to 600 mg daily were evaluated with no significant additional benefit and an increase in adverse effects. The initial dose in the treatment of epilepsy is 150 mg daily increased after 1 week according to response to 300 mg daily and then to 600 mg daily after another week.
In the treatment of generalized anxiety disorder, the initial dose is 150 mg daily; this may be increased at weekly intervals in steps of 150 mg, to a maximum of 600 mg daily.
For fibromyalgia the initial dose is 150 mg daily increased after 1 week according to response to 300 mg daily and then to 450 mg daily if necessary.
When discontinuing, taper off gradually over at least 1 week. (See table.)

Click on icon to see table/diagram/image

Post-hemodialysis supplementary dosage (as a single additional dose): 25 mg/day schedule: Single supplementary dose of 25 mg or 50 mg.
25-50 mg/day schedule: Single supplementary dose of 50 mg or 75 mg.
50-75 mg/day schedule: Single supplementary dose of 75 mg or 100 mg.
75 mg/day schedule: Single supplementary dose of 100 mg or 150 mg.
Dosage adjustment in hepatic impairment: No dosage adjustment expected since undergoes minimal hepatic metabolism.
Mode of Administration: Pregabalin may be administered with or without food.