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Pemetrexed may cause fetal harm when administered to a pregnant woman. Pemetrexed was fetotoxic and teratogenic in animal studies. There are no studies of pemetrexed in pregnant women. Patients should be advised to avoid becoming pregnant. If pemetrexed is used during pregnancy, or if the patient becomes pregnant while taking pemetrexed, the patient should be apprised of the potential hazard to the fetus.
It is not known whether pemetrexed or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from pemetrexed, it is recommended that nursing be discontinued if the mother is treated with pemetrexed.
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