Pexitaz Overdosage

There have been few cases of pemetrexed overdose. Reported toxicities included neutropenia, anemia, thrombocytopenia, sensory polyneuropathy, mucositis, and rash. Anticipated complications of overdose include bone marrow suppression as manifested by neutropenia, thrombocytopenia, and anemia. In addition, infection with or without fever, diarrhea, and mucositis may be seen. If an overdose occurs, patients should be monitored with blood counts and general supportive measures should be instituted as deemed necessary by the treating physician. The use of calcium folinate/folinic acid in the management of pemetrexed overdose should be considered.
In clinical trials, leucovorin was permitted for NCI CTC Grade 4 leukopenia lasting ≥3 days, CTC Grade 4 neutropenia lasting ≥3 days, and immediately for CTC Grade 4 thrombocytopenia, bleeding associated with Grade 3 thrombocytopenia, or Grade 3 or 4 mucositis. The following intravenous doses and schedules of leucovorin were recommended for intravenous use: 100 mg/m², intravenously once, followed by leucovorin, 50 mg/m², intravenously every 6 hours for 8 days.
The ability of pemetrexed to be dialyzed is unknown.