Incompatibilities: Reconstitution and further dilution prior to intravenous infusion is only recommended with 0.9% Sodium Chloride Injection. Pemetrexed is physically incompatible with diluents containing calcium, including Lactated Ringer's Injection and Ringer's Injection. Coadministration of pemetrexed for injection with other drugs and diluents has not been studied, and therefore is not recommended.