Pexitaz Side Effects

The adverse events reported with the use of pemetrexed include neutropenia, leukopenia, anemia, thrombocytopenia, ALT elevation, AST elevation, decrease creatinine clearance, creatinine elevation, renal failure, thrombosis, embolism, cardiac ischemia, nausea, vomiting, constipation, anorexia, stomatitis, pharyngitis, diarrhea without colostomy, dehydration, dysphagia, esophagitis, odynophagia, dyspnea, chest pain, hypertension, sensory neuropathy, mood alteration, depression, infection without neutropenia, infection with grade 3 or grade 4 neutropenia, febrile neutropenia, allergic reaction, hypersensitivity, rash, desquamation, conjunctivitis, taste disturbance, pyrexia, fatigue, fever, edema, myalgia, alopecia, dyspepsia, urticaria, arrhythmias, motor neuropathy, pruritis, erythema multiforme, abdominal pain, heart burn, GGT increase, arthralgia and other constitutional symptoms.
Serious cardiovascular and cerebrovascular events, including myocardial infarction, angina pectoris, cerebrovascular accident, and transient ischaemic attack, have been uncommonly reported during clinical studies with pemetrexed, usually when given in combination with another cytotoxic agent. Most of the patients in whom these events have been observed had pre-existing cardiovascular risk factors. Rare cases of hepatitis, potentially serious, have been reported during clinical studies with pemetrexed. Pancytopenia has been uncommonly reported during clinical trials with pemetrexed. In clinical trials, cases of colitis (including intestinal and rectal bleeding, sometimes fatal, intestinal perforation, intestinal necrosis and typhlitis) have been reported uncommonly in patients treated with pemetrexed. In clinical trials, cases of interstitial pneumonitis with respiratory insufficiency, sometimes fatal, have been reported uncommonly in patients treated with pemetrexed.
The following adverse events have been identified during post-marketing use of pemetrexed. These events have occurred with pemetrexed when used as a single agent and in combination therapies. These events included rare cases of colitis, interstitial pneumonitis, acute renal failure and radiation recall.