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In patients with moderate (creatinine clearance <50 mL/min) to severe (creatinine clearance <10 mL/min) renal impairment, dosage reduction or prolong interval should be considered for preventing drug accumulated, CNS adverse effects and risk of prolonged QT interval.
PEPFAMIN should be used with caution in pregnant patients, breast-feeding mothers, and children, because there are no adequate and controlled studies to date using Famotidine in these populations. In elderly patients with impaired renal function, the dose of PEPFAMIN should be reduced.
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