Pepfamin: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Famotidine

Indications/Uses

Acute duodenal ulcer; active benign gastric ulcer; GERD including GERD-associated esophagitis; pathologic GI hypersecretory conditions eg, Zollinger-Ellison syndrome. Prophylaxis of recurrent duodenal ulcer.

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Dosage/Direction for Use

Duodenal ulcer Acute therapy: 40 mg at bedtime or 20 mg bid for 4-8 wk. Maintenance therapy: 20 mg at bedtime for 1 yr or as clinically indicated. Benign gastric ulcer 40 mg at bedtime for 6-8 wk. GERD 20 mg bid for up to 6 wk. Esophagitis associated w/ GERD 20-40 mg bid for up to 12 wk. Pathologic GI hypersecretory conditions Initial adult dose: 20 mg every 6 hr, may increase up to max of 160 mg every 6 hr. Adult w/ moderate & severe renal insufficiency 50% of normal dose every 36-48 hr.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

History of hypersensitivity to famotidine or other H₂-receptor antagonist.

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Warnings

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Special Precautions

Consider dose reduction or longer intervals in patients w/ moderate (CrCl <50 mL/min) to severe (CrCl <10 mL/min) renal impairment. Pregnancy. Discontinue treatment or breastfeeding during lactation. Childn. Elderly w/ impaired renal function.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, dizziness; constipation, diarrhea. SJS, TEN.

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Drug Interactions

Reduced systemic exposure to ketoconazole. Decreased GI absorption & plasma conc of itraconazole. Increased conc w/ probenecid. Reduced efficacy of atazanavir.

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Storage

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Description

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Action

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MIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BA03 - famotidine ; Belongs to the class of H2-receptor antagonists. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Thai FDA Category

Presentation/Packing

Form

Pepfamin tab 20 mg

Packing/Price

10 × 10's

Pepfamin

famotidine

Manufacturer:

Siam Bheasach

Distributor:

Siam Pharmaceutical