Sign Out
1. Concomitant use of gastric suppressant agent, including histamine-2 receptor antagonists such as Famotidine, with ketoconazole is not recommended as systemic exposure to ketoconazole may be significantly reduced leading to ketoconazole loss of efficacy. Ketoconazole should be given two hours before Famotidine administration.
2. Concomitant use of itraconazole with Famotidine, agent that suppress gastric pH, may result in decreased gastrointestinal absorption of itraconazole and decreased itraconazole plasma concentrations.
3. Concomitant use of probenecid and Famotidine should be avoided because it has been reported to result in increased in Famotidine concentration due to a decline in renal tubular secretion.
4. Antacids appear to slightly decrease the bioavailability of Famotidine but this effect does not appear to be clinically important, Famotidine can be administered concomitantly with antacids.
5. Famotidine does not appear to inhibit the metabolism of drugs, including warfarin, theophylline, phenytoin, or diazepam, by the hepatic cytochrome P-450 (microsomal) enzyme system.
6. Concomitant use of atazanavir and Famotidine has resulted in reduced atazanavir efficacy because of alteration of gastric pH may affect absorption atazanavir.
Continue with Google