Pepfamin Dosage/Direction for Use

Duodenal ulcer: Acute therapy: Recommended oral dose is 40 mg at bedtime or 20 mg twice daily for 4-8 weeks. In most cases healing may occur within 4 weeks. Treatment should be continued for another 4 weeks in patients whose ulcer has not healed completely within 4 weeks.
Maintenance therapy: Recommended oral dose is 20 mg at bedtime for 1 year or as clinically indicated.
Benign gastric ulcer: Recommended oral dose is 40 mg at bedtime for 6 to 8 weeks.
Gastroesophageal Reflux Disease (GERD): Recommended oral dosage is 20 mg twice daily for up to 6 weeks.
Esophagitis associated with GERD: Recommended oral dosage is 20-40 mg twice daily for up to 12 weeks.
Pathologic GI hypersecretory conditions: The usual initial adult dosage is 20 mg orally every 6 hours; may increase dose based on patient response up to maximal dosage of 160 mg every 6 hours.
Dosage in renal impairment: In adults with moderate and severe renal insufficiency, the elimination half-life will be exceeded 20 hours and up to 24 hours in anuric patients. To avoid drug accumulated, dosage should be decreased 50% of normal dose and the dosing interval should be increased to every 36 to 48 hours for preventing CNS adverse effects.
Dosage in elderly: Clinically important changes in the pharmacokinetics of Famotidine have not been observed in geriatric individuals, and dosage of the drug does not need to be modified based on age alone. However, in elderly patients with lower renal function, renal clearance will be decreased. Thus, dosage adjustment should be considered.
Dosage in hepatic impairment: Dosage adjustment is not necessary in patients with hepatic impairment.