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Oxol

Oxol

oxaliplatin

Manufacturer:

Venus Remedies

Distributor:

Cosma Medical
Concise Prescribing Info
Contents
Oxaliplatin
Indications/Uses
In combination w/ 5-fluorouracil (5-FU) & leucovorin for metastatic CRC; unresectable advanced or metastatic gastric cancer; unresectable hepatocellular carcinoma; adjuvant treatment of stage III (Duke's C) colon cancer after complete resection of primary tumor.
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Dosage/Direction for Use
IV infusion Adult Metastatic CRC 85 mg/m2 every 2 wk. Unresectable advanced or metastatic gastric cancer Combination w/ infusional 5-FU & folinic acid: 100 mg/m2 every 2 wk. Combination w/ fluorouracil & leucovorin (FLO regimen): oxaliplatin 85 mg/m2 + fluorouracil 2,600 mg/m2 & leucovorin 200 mg/m2 every 2 wk; modified FOLFOX regimen: oxaliplatin 85 mg/m2 + fluorouracil 1,000 mg/m2 & leucovorin 200 mg/m2 every 2 wk. Combination w/ epirubicin & capecitabine or fluorouracil (EOX or EOF regimen): oxaliplatin 130 mg/m2 + epirubicin 50 mg/m2 & capecitabine 625 mg/m2 or fluorouracil 200 mg/m2. Unresectable hepatocellular carcinoma 85 mg/m2 in combination w/ 5-FU & folinic acid every 2 wk. Adjuvant setting 85 mg/m2 every 2 wk for 12 cycles (6 mth). Severe renal impairment, persistent grade 2 neurosensory events 65 mg/m2.
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Overdosage
View Oxol overdosage for action to be taken in the event of an overdose.
Contraindications
Allergy to oxaliplatin or other platinum compd.
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Special Precautions
Hypersensitivity & anaphylactic/anaphylactoid reactions. Discontinue in case of extravasation; unexplained resp symptoms eg, non-productive cough, dyspnea, crackles or radiological pulmonary infiltrates. Acute & persistent peripheral sensory neuropathy. Exposure to cold or cold objects may precipitate acute neurosensory toxicity. Fever w/ persistent diarrhea or evidence of infection; vomiting, signs of dehydration, cough or breathing difficulties. Monitor WBC, Hb, platelet count, AST, ALT, bilirubin & creatinine before each treatment cycle. Severe renal & hepatic impairment. Avoid becoming pregnant while on treatment. Lactation. Ped.
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Adverse Reactions
Anemia, diarrhea, emesis, fatigue, increase in transaminases & alkaline phosphatase, nausea, neutropenia, peripheral sensory neuropathy, stomatitis & thrombocytopenia.
Drug Interactions
Increased plasma conc of 5-FU. Decreased clearance w/ nephrotoxic compd. Avoid use w/ intravesical BCG, deferiprone, dipyrone, natalizumab, pimecrolimus, topical tacrolimus, live vaccines. Increased effect/toxicity of clozapine, deferiprone, fingolimod, leflunomide, natalizumab, highest & moderate risk QTc-prolonging agents, taxane derivatives, tofacitinib, topotecan, live vaccines. Increased levels/effects w/ bupropion, ophth chloramphenicol, denosumab, dipyrone, mifepristone, ocrelizumab, palifermin, pimecrolimus, promazine, roflumilast, topical tacrolimus, trastuzumab. Decreased levels/effects of intrevesical BCG, Coccidioides immitis skin test, fosphenytoin-phenytoin, lenograstim, lipegfilgrastim, nivolumab, pidotimod, sipuleucel-T, tertomotide, inactivated & live vaccines. Decreased levels/effects w/ Echinacea.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Oxol detailed prescribing information
Storage
View Oxol storage conditions for details to ensure optimal shelf-life.
Description
View Oxol description for details of the chemical structure and excipients (inactive components).
Action
View Oxol mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01XA03 - oxaliplatin ; Belongs to the class of platinum-containing antineoplastic agents. Used in the treatment of cancer.
Patient Counseling Information
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Presentation/Packing
Form
Oxol infusion 100 mg/50 mL
Packing/Price
1's
Form
Oxol infusion 50 mg/25 mL
Packing/Price
1's
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