Oxol Caution For Usage

PREPARATION OF INFUSION SOLUTION: The solution must be further diluted in an infusion solution of 250-500 mL of 5% Dextrose injection USP.
DILUTION MUST NEVER BE MADE WITH A SODIUM CHLORIDE SOLUTION OR OTHER CHLORIDE-CONTAINING SOLUTIONS.
The concentration over which the physico-chemical stability of OXOL has been demonstrated is 2.0 mg/mL. After dilution in 5% glucose solution, chemical and physical in-use stability has been demonstrated for 12 hours at 25°C or up to 24 hours under refrigeration (2-8°C [36-46°F]).
From a 'microbiological' point of view, this infusion preparation should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of user and would normally not be longer 24 hours at 2° to 8°C unless dilution has taken place in controlled and validated aseptic conditions.
Oxaliplatin is incompatible in solution with alkaline medications or media (such as basic solutions of 5-FU) and must not be mixed with these or administered simultaneously through the same infusion line. The infusion line should be flushed with D5W prior to administration of any concomitant medication.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration and discarded if present.
Needles or intravenous administration sets containing aluminum parts that may come in contact with OXOL should not be used for the preparation or mixing of the drug. Aluminum has been reported to cause degradation of platinum compounds.
HANDLING AND DISPOSAL: As with other potentially toxic anticancer agents, care should be exercised in the handling and preparation of infusion solutions prepared from OXOL. The use of gloves is recommended. If a solution of OXOL contacts the skin, wash the skin immediately and thoroughly with soap and water. If OXOL contacts the mucous membranes, flush thoroughly with water.