Oxol Side Effects

The most common adverse reactions in patients with stage II or III colon cancer receiving adjuvant therapy were anemia, diarrhea, fatigue, increase in transaminases and alkaline phosphatase, nausea, neutropenia, peripheral sensory neuropathy, stomatitis, and thrombocytopenia. The most common adverse reactions in previously untreated and treated patients were diarrhea, emesis, fatigue, nausea, neutropenia and peripheral sensory neuropathies.
Cardiovascular: Chest pain, edema, flushing, peripheral edema, thromboembolism.
Central nervous system: Dizziness, fatigue, headache, insomnia, pain, peripheral neuropathy (may be dose limiting), rigors.
Dermatologic: Alopecia, palmar-plantar erythrodysesthesia, skin rash.
Endocrine & metabolic: Dehydration, hypokalemia.
Gastrointestinal: Abdominal pain, anorexia, constipation, diarrhea, dysgeusia, dyspepsia, dysphagia (acute), flatulence, gastroesophageal reflux disease, hiccups, mucositis, nausea, stomatitis, vomiting.
Genitourinary: Dysuria.
Hematologic & Oncologic: Anemia, leukopenia, neutropenia, thrombocytopenia.
Hepatic: Increased serum ALT, increased serum AST, increased serum bilirubin.
Hypersensitivity: Hypersensitivity reaction (includes urticaria, pruritus, facial flushing, shortness of breath, bronchospasm, diaphoresis, hypotension, syncope).
Local: Injection site reaction (redness, swelling, pain).
Neuromuscular & skeletal: Arthralgia, back pain.
Ocular: Abnormal lacrimation.
Renal: Increased serum creatinine.
Respiratory: Cough, dyspnea, epistaxis, pharyngitis, pharyngolaryngeal dysesthesia, rhinitis, upper respiratory tract infection.
Miscellaneous: Fever.
Rare but important or life-threatening: Acute renal failure, anaphylactic shock, anaphylactoid reaction, aphonia, ataxia, blepharoptosis, cerebral hemorrhage, colitis, cranial nerve palsy, decreased deep tendon reflex. deafness, decreased visual acuity, diplopia, eosinophilic pneumonitis, fasciculations, febrile neutropenia, hematuria, hemolysis, hemolytic anemia (immune-allergic), hemolytic-uremic syndrome, hemorrhage, hepatic failure, hepatic fibrosis (perisinusoidal), hepatic sinusoidal obstruction syndrome (SOS; veno-occlusive disease), hepatitis, hepatotoxicity, hypertension, hypomagnesemia, hypoxia. idiopathic noncirrhotic portal hypertension (nodular regenerative hyperplasia), increased INR, increased serum alkaline phosphatase, infusion related reaction (extravasation [including necrosis]), interstitial nephritis (acute), interstitial pulmonary disease, intestinal obstruction, Lhermitte's sign, metabolic acidosis, myoclonus, neutropenic enterocolitis, neutropenic infection (sepsis), optic neuritis, pancreatitis, prolonged prothrombin time, pulmonary fibrosis, prolonged Q-T interval on ECG, purpura, rectal hemorrhage, renal tubular necrosis, reversible posterior leukoencephalopathy syndrome (RPLS), rhabdomyolysis, seizure, sepsis, septic shock, temporary vision loss, thrombocytopenia (immune-allergic), torsades de pointes, trigeminal neuralgia, ventricular arrhythmia, visual field loss.