Oralax-C Special Precautions

Should be used with caution in patients with impaired gag reflex, unconscious or semi-conscious patients, and those prone to regurgitation or aspiration; these patients should be observed during administration.
If severe discomfort or distention occurs while consuming polyethylene glycol solutions, administration of the drug should be slowed or temporarily discontinued until symptoms abate.
Patients with angina pectoris or patients with old myocardial infarction. (As product can give a chilliness in the body, chest pain may rarely occur.)
Patients with impaired renal. (Vomiting may rarely occur.)
Important Basic precautions: Since Mallory-Weiss syndrome, intestinal perforation and colitis ischaemic may nearly occur, the following points should be kept in mind: Since Mallory-Weiss syndrome can occur due to gastric internal pressure increased, vomiting, nausea, administration in a short period of time should be avoided (dosing should be given at a rate of 1 L/hour as a guide). Furthermore, since intestinal stricture or retention of product or the intestinal contents may cause nausea or vomiting. Thereby triggering the onset of the syndrome. Careful administration is required.
Since intestinal perforation and colitis ischaemic can be produced by the intestinal pressure increased, in case of intestinal stricture or retention of intestinal contests such as in case of constipation, careful administration is required. Administration should be given after making sure that was defecation on the previous day before administration of product on the day. Further, administration in a short period of time which may give rise to the intestinal pressure increased, should be avoided (dosing should be given at a rate of 1 L/hour as a guide). In addition, in case of absence of defecation after dosing about 1 L, dosing should be resumed upon identifying the absence of nausea, vomiting and abdominal pain, and close monitoring should be exercised until defecation is seen. Since it has been reported that in a patient having prior diverticulum intestinal, intestinal perforation was triggered by the intestinal internal pressure increased, particular caution should be exercised.
When any other ingredient or flavor is added to the dissolved solution of product, osmotic pressure or concentration of electrolyte may change or inflammable gas may be produced due to enterobacterium; therefore, addition, in a such substance should be avoided.
In the case of letting patients take the drug at home, the following points should be kept in mind: Since taking countermeasures may occasionally be difficult in case of adverse reaction, patients should be guided in a fashion to avoid taking the drug when there is nobody else nearby.
Particularly, patients should be guided to take the initial two or three glassfuls of product in a slow fashion and to pay attention to the signs of anaphylactoid symptoms.
Patient should be provided explanation of product adverse reaction such as digestive symptoms (nausea, vomiting, abdominal pain, etc.) shock, anaphylactoid symptoms and so on, and when such symptoms appear, they should discontinue medication and consult their physician without delay. Moreover, since similar symptoms may arise even after medication, when such symptoms appear, the patients should consult their physician without delay.
Administration to patients receiving insulin or an oral hypoglycemic agent: In the case of patients whose blood glucose is being controlled by insulin or an oral hypoglycemic agent, administration of product on the day preceding examination should be avoided. Patients should be given product on the day of examination under close observation, dosing of insulin or an oral hypoglycemic agent should be started after dietary intake on the day of examination (because dietary restriction may cause hypoglycemia).
Effect on the absorption drugs: Since intestinal lavage by product may disturb the absorption of an orally administration drug, caution should be exercised as to dosing time. Moreover, in patients on any drug which can cause clinically serious problems once its absorption is inhibited, administration should be exercised while closely monitoring the patient's condition in the hospital.