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Overdose: Acute toxicity increases with decreasing molecular weight of polyethylene glycol. Solid forms of polyethylene glycol have a higher molecular weight (MW greater than 3000) and are not readily absorbed with oral ingestion, therefore these formulations rarely produce toxicity. Overdose could lead to diarrhea, excessive fluid loss by diarrhea or vomiting.
Treatment: There is no specific antidote. Treatment is symptomatic and supportive. Patients will generally recover with supportive care. Diarrhea which disappears when treatment is temporarily interrupted or the dosage is reduced. Excessive fluid loss by diarrhea or vomiting may require correction of electrolyte disturbances.
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