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Pharmacology: Pharmacodynamics: High molecular weight polyethylene glycol are long linear polymers which retain water molecules by means of hydrogen bonds. When administered by oral route, they lead to an increase in volume of intestinal fluids. The volume of unabsorbed intestinal fluid accounts for laxative properties of solution. Polyethylene glycol is an osmotic agent that causes retention of water in the stool resulting in a softer stool and more frequent bowel movements.
Pharmacokinetics: Polyethylene glycols of high molecular weight are not significantly absorbed from gastrointestinal tract. The pharmacokinetic data confirm that polyethylene glycol 4000 undergoes neither gastrointestinal resorption nor biotransformation following oral ingestion.
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