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The symptom includes arrhythmia, drowsiness, disorientation, extrapyramidal reactions, hypotension; they are self limiting and usually disappear within 24 hours. Close observation and supportive therapy are recommended.
There is no specific antidote for the overdose. However, anticholinergic agents, antiparkinsonian medications, or antihistamines with anticholinergics properties may be useful in controlling the extrapyramidal reactions associated with Domperidone toxicity.
Gastric lavage as well as the administration of activated charcoal may be useful in facilitating the elimination of Domperidone.
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