Molax/Molax-M Dosage/Direction for Use

Recommended dose: Adult dose and adolescents (over 12 years old and weighing 35 kg or more): For the treatment of nausea and vomiting: 10 to 20 mg, 3 or 4 times daily; 15-30 minutes before meals and, if necessary, before bed.
For the symptomatic treatment of dyspepsia: 10 to 20 mg 4 times daily; 15-30 minutes before meals and before bed.
The maximum daily dose is 80 mg.
Pediatric dose: Use MOLAX SUSPENSION 0.25 to 0.5 mg/kg, 3 or 4 times daily; 15-30 minutes before meals and, if necessary, before bed.
The maximum daily pediatric dose is 2.4 mg/kg, and does not exceed 80 mg.
Administration: It is recommended to take the drug before meals to avoid absorption delay.
Concomitant antacids or antisecretory agents can be taken together with MOLAX-M TABLET.
However, MOLAX SUSPENSION should not be taken simultaneously as the oral availability will be lowered.
Hepatic impairment: Domperidone is highly metabolized in liver. Patients with mild hepatic impairment have a lower systemic exposure than healthy subjects with no change in protein binding and terminal elimination half-life. Patients with moderate impairment, however, have higher drug levels than healthy subjects, with prolonged terminal half-life, and increased unbound fraction. There are no studies in patients with severe impairment. Therefore, it is recommended to use caution in patients with mild hepatic impairment. The use in patients with moderate and severe hepatic impairment is contraindicated.
Renal impairment: Dosage adjustment of single acute administration in patients with renal dysfunction is not necessary since renal clearance is small compared to total plasma clearance. On repeated administration, however, the dosing frequency should be reduced to once or twice daily because of the increased elimination half-life, depending on the severity of the impairment; and the dose may need to be reduced. The patients on prolonged therapy should also be reviewed regularly.