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Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use with KOACT may result in increased and prolonged blood level of amoxicillin but not of clavulanate.
Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Co-amoxiclav and allopurinol.
KOACT may reduce the efficacy of oral contraceptives and patients should be recommended to use other contraceptive method such as use of condom.
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