Koact 1000: Dosing, Side Effect & Interaction

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Co-amoxiclav (amoxicillin & clavulanic acid). Per 1 g FC tab Amoxicillin 875 mg, clavulanic acid 125 mg

Indications/Uses

Short-term treatment of susceptible bacterial infections of upper resp tract (including ENT) eg, sinusitis, otitis media; lower resp tract eg, acute exacerbations of chronic bronchitis, bronchopneumonia; GUT eg, cystitis; skin & soft tissue eg, cellulitis caused by E. coli, Klebsiella & Enterobacter spp.

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Dosage/Direction for Use

Max treatment duration: 14 days. Adult Severe infections 1 tab every 12 hr for 7-10 days. Ped ≥12 yr weighing ≥40 kg Adult dose recommendation.

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Overdosage

View Koact 1000 overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food: Best taken at the start of meals for optimized absorption & to minimize GI intolerance.

Contraindications

History of hypersensitivity to co-amoxiclav or β-lactams eg, penicillins & cephalosporins; co-amoxiclav-associated jaundice/hepatic dysfunction.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Koact 1000 detailed prescribing information

Special Precautions

History of hypersensitivity reactions to penicillins, cephalosporins or other allergens. Not to be used in patient w/ known hypersensitivity. Discontinue treatment if erythema rash, irritation or edema; flu-like symptoms; signs of SJS [eg, fever, rash, bullae, exfoliation of skin & other mucous membranes (eg, mouth, throat, nose, genitalia), or conjunctivitis] occur. Overgrowth of non-susceptible organisms w/ prolonged use. May cause cholestatic jaundice or rise of hepatic enzyme (cause hepatic dysfunction). Maintain adequate fluid intake during high-dose treatment to reduce possibility of amoxicillin crystalluria. Monitor hepatic function at regular intervals. Increased effect of warfarin in prolongation of prothrombin time w/ concomitant use. Not to be given in severe renal impairment (GFR <30 mL/min). Not recommended in hepatic impairment. Avoid use in pregnancy (especially during 1st trimester). Lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Diarrhea. Mucocutaneous candidiasis; nausea, vomiting. SJS, TEN.

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Drug Interactions

Reduced efficacy of OCs. Amoxicillin: Decreased renal tubular secretion w/ probenecid. Increased allergic skin reactions w/ allopurinol.

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Storage

View Koact 1000 storage conditions for details to ensure optimal shelf-life.

Description

View Koact 1000 description for details of the chemical structure and excipients (inactive components).

Action

View Koact 1000 mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antibacterial Combinations

ATC Classification

J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Thai FDA Category

Presentation/Packing

Form

Koact 1000 FC tab 1,000 mg

Packing/Price

20 × 5's;2 × 5's

Koact 1000

amoxicillin + clavulanic acid

Manufacturer:

Aurobindo

Distributor:

Biopharm

Marketer:

Biopharm