Sign Out
Pharmacology: Pharmacodynamics: Resistance to many antibiotics is caused by bacterial enzymes which destroy the antibiotic before it can act on the pathogen. The clavulanate in KOACT anticipates this defense mechanism by blocking the β-lactamase enzymes, thus rendering the organisms susceptible to amoxicillin's rapid bactericidal effect.
KOACT is an antibiotic agent of broad spectrum.
KOACT is bactericidal to a wide range of organisms including: Gram-positive: Aerobes: Bacillus anthracis*, Enterococcus faecalis*, Streptococcus pneumoniae, Streptococcus viridans, Staphylococcus aureus*, Staphylococci*.
Anaerobes: Clostridium species, Peptococcus species, Peptostreptococcus.
Gram-negative: Aerobes: Escherichia coli*, Haemophilus influenzae*, Klebsiella species*, Moraxella catarrhalis* (Branhamella catarrhalis), Neisseria gonorrhoeae*, Neisseria meningitidis*, Proteus mirabilis*, Proteus vulgaris*.
Anaerobes: Bacteroides species* including B. fragilis.
* Some members of these species of bacteria produce β-lactamase, rendering them insensitive to amoxicillin alone.
Pharmacokinetics: The pharmacokinetics of the two components of KOACT are closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of KOACT is optimized at the start of a meal. Both clavulanate and amoxicillin have low levels of serum binding (18% and 25%); about 70% remains free in the serum.
Continue with Google