Koact 1000 Dosage/Direction for Use

Adults: The usual adult dose is one tablet of KOACT 625 every 12 hours or one tablet of KOACT 375 every 8 hours.
For more severe infections, the dose should be one tablet of KOACT 1000 every 12 hours or one tablet of KOACT 625 every 8 hours, 7-10 days continuously.
Patients with impaired renal function: Do not generally require a reduction in dose unless the impairment is severe.
Severely impaired patients with a glomerular filtration rate of <30 mL/min. should not receive the 1000 mg tablet.
Patients with a glomerular filtration rate of 10 to 30 mL/min. should receive 375 mg or 625 mg two times a day or every 12 hours, depending on the severity of the infection.
Patients with a less than 10 mL/min glomerular filtration rate should receive not more than 375 mg two times a day or every 12 hours, if higher dose is necessary, it should be under consideration of the physician.
Hemodialysis patients should receive 625 mg or 375 mg every 24 hours, depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis.
Hepatically Impaired patients: Use of KOACT is not recommended unless considered essential by the physician, and hepatic function monitored at regular intervals.
Pediatric Patients: Pediatric patients weighing 40 kg or more, or age over 12 years should be dosed according to the adult recommendations.
Dosage in renal impairment: Dosage reductions are similar to that of adult recommendation.
Dosage in hepatic impairment: Use of KOACT is not recommended unless considered essential by the physician, and hepatic function monitored at regular intervals. There are, as yet, insufficient data on which to base a dosage recommendation.
Administration: To minimize the potential gastrointestinal intolerance, administer at the start of a meal. The absorption of KOACT is optimized when taken at the start of a meal.
Treatment should not be extended beyond 14 days without review.