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The drug should be used with caution in patients with known sulfonamide sensitivity as it may show allergic actions to Furosemide.
Long term use of diuretics include Furosemide may result in dehydration and reduction of blood volume with circulatory collapse and possibly vascular thrombosis and embolism, especially in elderly.
Electrolyte imbalance may occur after a long term used of Furosemide. Therefore, periodic determinations of serum electrolytes, for signs of fluid or electrolyte imbalance such as hyponatremia, hypokalemia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis.
The drug should be used with caution in patients with hepatic cirrhosis as sudden alterations of electrolyte balance may precipitate and leads to coma.
The treatment with Furosemide can increase the level of serum uric acid and therefore may cause an exacerbation of hyperuricemia.
The drug can cause hearing impairment (such as tinnitus) and ototoxicity.
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