Furetic/Furetic-S Drug Interactions

Administration of Furosemide with insulin or anti-diabetic agents; such as sulfonylureas, may interfere with the hypoglycemic effect. Therefore, plasma glucose level should be closely monitored when coadministration is used.
The use of Furosemide with other antihypertensive agents may potentiate the hypotensive effects, causing orthostatic hypotension. Therefore, the dose should be adjusted when there is a concomitant used.
Coadministration of the drug with thiazide diuretics will result in electrolyte abnormalities and therefore the drug should be used with caution.
Administration of Furosemide with digitalis may cause potassium depletion (resulting in increasing sensitivity of cardiac muscle to digitalis) and cardiac arrhythmias.
Coadministration of Furosemide with glucocorticoid, corticosteroid, corticotrophin and amphotericin B will decrease potassium level.
Concomitant use of Furosemide with aminoglycosides may increase ototoxicity. Therefore, avoid coadministration.
Administration of Furosemide with phenytoin or indomethacin and other NSAIDs may reduce the efficacy of Furosemide.
The use of Furosemide with lithium is contraindicated as diuretics will reduce the clearance of lithium, resulting in lithium toxicities.
The use of Furosemide with beta blocker such as propranolol may increase the plasma level of propranolol. Therefore, the drug should be used with caution.