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Pharmacology: Pharmacodynamics: Furosemide is a diuretic, inhibits the reabsorption of sodium, chloride and water at ascending limb of the loop of Henle and therefore excretion of sodium and water is increased. Moreover, Furosemide can increase the excretion of potassium at distal tubule with an independent of any inhibitory effect on carbonic anhydrase or aldosterone.
Pharmacokinetics: The drug can cross placenta and distributed into breast milk. Approximately 90-95% of the drug bound to plasma protein. Furosemide is primarily excreted in urine and some portion of the drug is metabolized in liver. The reminder of the drug is eliminated by degradation in liver or excretion of unchanged drug in feces. The half-life of the drug is approximately 120 minutes.
Furosemide is not removed by hemodialysis.
Furetic tablet: Furosemide will be absorbed in gastrointestinal tract after an oral administration with peak plasma concentration reached within 60-120 minutes.
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