Epitam 500 Drug Interactions

Concomitant use of levetiracetam and other anticonvulsants (e.g., carbamazepine, gabapentin, lamotrigine, phenobarbital, phenytoin, primidone, valproic acid) does not appear to affect the pharmacokinetics of levetiracetam.
Concomitant use of levetiracetam and digoxin does not appear to affect the pharmacokinetics or pharmacodynamics (e.g., cardiac rhythm effects) of digoxin; digoxin also does not affect the pharmacokinetics of levetiracetam.
Concomitant use of levetiracetam and oral contraceptives does not appear to affect the pharmacokinetics of oral contraceptives.
Concomitant use of levetiracetam and probenecid does not effect on levetiracetam pharmacokinetics was observed, but steady-state plasma concentrations of the principal inactive metabolite were approximately doubled due to a 60% reduction in renal clearance.
Concomitant use of levetiracetam and warfarin does not appear to affect the pharmacokinetics or pharmacodynamics (e.g., prothrombin time) of warfarin; warfarin also does not affect the pharmacokinetics of levetiracetam.