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Immunologic: infectious disease (13%).
Musculoskeletal: decreased bone mineral density (70%), neck pain (2% to 8%).
Neurologic: asthenia (15%), dizziness (5% to 9%), headache (14% to 19%).
Psychiatric: abnormal behavior (7% to 37.6%), irritability (6% to 12%).
Respiratory: cough (2% to 9%), nasopharyngitis (7% to 15%).
Other: fatigue (10% to 11%).
Serious: Dermatologic: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Hematologic: decreased erythrocyte production, decreased white blood cell count (2.4% to 3.2%), eosinophil count raised (8.6%), neutropenia (2.4%), pancytopenia, thrombocytopenia.
Hepatic: liver failure.
Immunologic: anaphylaxis.
Neurologic: somnolence (8% to 45%).
Psychiatric: suicidal intent (0.5%), suicide.
Other: Angioedema.
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