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Pharmacology: Pharmacodynamics: Diclofenac actions are similar to those of other prototypical nonsteroidal anti-inflammatory agent (NSAIDs). Diclofenac inhibits the synthesis of prostaglandins in body tissues by inhibiting cyclooxygenase; cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which have been identified to catalyze the formation of prostaglandins in the arachidonic acid pathway. However, the exact mechanisms have not been clearly established.
Pharmacokinetics: When Diclofenac is applied topically, it is absorbed into the epidermis. Diclofenac binds tightly to serum albumin. Diclofenac and its metabolites are excreted in the urine mainly.
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