Diaglip

Adjunct to diet & exercise in NIDDM (type II), may be used in combination w/ insulin or metformin.

Initially 1 mg once daily. Increase dose gradually at 1-2 wk intervals by the following dose steps: 1 mg, 2 mg, 3 mg, 4 mg, 6 mg or 8 mg. Well-controlled diabetes 1-4 mg once daily. Max: 8 mg daily. Switch from other oral hypoglycemics Recommended starting dose: 1 mg daily. Hepatic & renal impairment Initially 1 mg once daily.

Should be taken with food: Take w/ breakfast or w/ 1st main meal. Do not skip meals.

Hypersensitivity to glimepiride or other sulfonylureas or sulfonamides. Type 1 DM; diabetic ketoacidosis w/ or w/o coma; severe infection & accident. Severe renal or hepatic impairment. Pregnancy & lactation.

Discontinue use if SJS symptoms occur eg, skin rash, blisters, detachment of skin & epithelial lining in oral cavity, throat, nose, genital organ & conjunctivitis. Hypo-/hyperglycemia. Advise patients not to neglect dietary restrictions or disregard instruction about exercise, body wt control, hygiene including regular drug intake & avoidance of infection, alcohol & stress. Monitor plasma & urine glucose conc including HbA1c regularly. Avoid alcohol intake. Renal impairment. Not to be taken during pregnancy & lactation.

Hypoglycemia; drowsiness, nervousness, tremor, insomnia, depression, confusion, headache, fatigue, weakness, paresthesia, visual disorder, sensory disturbances; pruritus, urticaria, eczema; nausea, vomiting, sensation of pressure, fullness in epigastrium, abdominal pain, diarrhea; leucopenia, thrombocytopenia, hemolytic anemia; decreased serum Na, skin hypersensitivity to light, dyspnea, fall in BP, liver failure sometimes progressing to shock.

Potentiated blood sugar-lowering effect w/ insulin, oral antidiabetics, ACE inhibitors, allopurinol, anabolic steroids & male sex hormones, chloramphenicol, coumarin derivative, cyclophosphamide, disopyramide, fenfluramine, fenyramidol, fibrates, fluoxetine, guanethidine, ifosfamide, MAOIs, miconazole, p-aminosalicylic acid, high dose parenteral pentoxifylline, oxyphenbutazone, probenecid, quinolones, salicylates, sulfinpyrazone, sulfonamides, tetracyclines, tritoqualine, trofosfamide. Weakened blood sugar-lowering effect w/ acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine (adrenaline) & other sympathomimetic agents, glucagon, laxatives (after protracted use), high dose nicotinic acid, oestrogens & progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones. Potentiated or weakened blood sugar-lowering effect w/ H₂-receptor antagonists, clonidine & reserpine. Decreased glucose tolerance & increased tendency to hypoglycemia w/ β-blockers.

Antidiabetic Agents

A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

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