Diaglip Adverse Reactions

Adverse reactions of Glimepiride must be considered: Hypoglycemia, especially in the initial weeks of treatment, the risk of hypoglycemia may be increased and necessitates especially careful monitoring. Factors favouring hypoglycemia include: Irregular intake of the dug, or overdosage with the drug, or concomitant administration of certain other medicines; Undernutrition, or irregular meal times, or alterations of diet; Severe or prolonged exercise; Consumption of alcohol, combination with skipped meal; Severe impairment of renal and/or hepatic function; Certain uncompensated disorders of the endocrine system affecting carbohydrate metabolism, for example, certain disorders of thyroid function and in anterior pituitary or adrenocortical insufficient.
Symptoms of hypoglycemia include headache, ravenous hunger, nausea, vomiting, lassitude, sleepiness, disordered sleep, restlessness, aggressiveness, impaired concentration, alertness and reactions, depression, confusion, difficult in speaking and even speech loss, visual disorders, tremor, paresis, sensory disturbances, dizziness, helplessness, loss of self-control, delirium, cerebral convulsions, somnolence and coma, shallow respiration and slow heart rate. In addition, signs may be present such as sweating, clammy skin, anxiety, rapid heart rate, hypertension, palpitations, angina pectoris, and cardiac arrhythmias. The clinical picture of a severe hypoglycemia may resemble that of a stroke. The symptoms of hypoglycemia nearly always subside when hypoglycemia is corrected.
Central Nervous System: drowsiness, nervousness, tremor, insomnia, depression, confusion, headache, fatigue, weakness, paresthesia, visual disorder, sensory disturbances.
Dermatologic: pruritus, urticaria, eczema.
Gastrointestinal: nausea, vomiting, sensation of pressure, fullness in the epigastrium, abdominal pain, diarrhea.
Hematologic: leucopenia, thrombocytopenia, hemolytic anemia.
Others: a decrease in serum sodium, hypersensitivity of skin to light, dyspnea, a fall in blood pressure, liver failure and sometimes progressing to shock.
If sudden or severe adverse reactions occur, inform a doctor immediately. The patient must be for under the supervision and suggestion of the doctor.