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Pharmacology: Pharmacodynamics: Glimepiride is a hypoglycemic agent of the sulfonylurea class. Glimepiride stimulates insulin release from the pancreatic beta cells. Glimepiride increases sensitivity of peripheral tissues to insulin.
Pharmacokinetics: Glimepiride is well absorbed from the gastrointestinal tract and peak plasma concentrations occur in 2 to 3 hours after oral administration. Duration of action is 24 hours. Glimepiride absorption is affected by food. Protein binding was greater than 99.5%. Glimepiride is metabolized by CYP2C9 and changed to be active metabolites. Urine excretion is major route, and fecal excretion is minor route. The half-life elimination of Glimepiride is about 5 to 9 hours.
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