Chalocaine Viscous Solution Drug Interactions

Antiarrhythmic drugs: Lidocaine should be used with caution in patients receiving antiarrhythmic drug such as mexiletine, since the Lidocaine toxicity are arising from the use of Lidocaine oral preparation.
Antiepileptics: The long-term use of phenytoin or barbiturates may increase dosage requirements for Lidocaine due to induction of drug-metabolising microsomal enzymes, appear to enhance the metabolism of Lidocaine. Phenytoin and Lidocaine have additive cardiac depressant effects.
Enzyme inducing drugs: Lidocaine should be used with caution in patients receiving Cimetidine and Beta blockers, these drugs have been shown to cause potentially toxic plasma concentrations when Lidocaine is given in repeated high doses over a long period of time.
Beta blockers: Significant increases in plasma Lidocaine concentrations have occurred with beta blockers such as propranolol, nadolol, and metoprolol due to reduction in the clearance of Lidocaine. The reduction in clearance produced by propranolol seems to be mainly by direct inhibition of hepatic microsomal enzymes.
H2 antagonists: The clearance of Lidocaine may be reduced by H2 antagonists, cimetidine appears to reduce the hepatic metabolism of Lidocaine, it may also reduce by decreasing hepatic blood flow.