Apreszine 25/Apreszine 50 Overdosage

Apreszine 25: Overdosage of hydralazine may produce hypotension, tachycardia, headache and generalized skin flushing. Myocardial ischemia and cardiac arrhythmia may develop; profound shock can occur in severe overdosage.
There is no specific antidote for the treatment of hydralazine overdosage. Support of the cardiovascular system is most important for the treatment of hydralazine overdosage. Evacuation of gastric contents using adequate precautions to protect the airway and prevent aspiration should be done only after cardiovascular status has been stabilized.
Apreszine 50: Symptoms: The signs and symptoms of hydralazine overdose include hypotension, tachycardia, headache and generalised skin flushing. Complications can include myocardial ischemia and subsequent myocardial infarction, cardiac arrhythmias, profound shock and coma.
Management: There is no specific antidote. Gastric lavage should be instituted as soon as possible, taking adequate precautions against aspiration and for protection of the airway. An activated charcoal slurry may be instilled if conditions permit. These procedures may have to be omitted or carried out after cardiovascular status has been stabilised since they might precipitate cardiac arrhythmias or increase the depth of shock.
Support of the cardiovascular system is of primary importance. Shock should be treated with plasma expanders if possible, rather than vasopressors. Supportive measures including intravenous fluids are also indicated. If hypotension is present, an attempt should be made to raise the blood pressure without increasing the tachycardia. If a vasopressor is used, one should be chosen that is least likely to precipitate or aggravate cardiac arrhythmia. Tachycardia responds to beta-blockers. Digitalisation may be necessary. Fluid and electrolyte status and renal function should be monitored.