Apreszine 25/Apreszine 50 Drug Interactions

Apreszine 25: Hydralazine may increase the levels/effects of Amifostine, Antipsychotic agents (second generation), Bromperidol, Duloxetine, Hypotension associated agents, Levodopa, Nitroprusside, Pholcodine.
The levels/effects of Hydralazine may be increased by Afuzosine, Barbiturates, Benperidol, Brigatinib, Brimonidine (Topical), Dapoxetine, Diazoxide, Herbs (Hypotensive properties), Lormetazepam, Molsidomine, Naftofpidil, Nicergoline, Nicorandil, Obinutuzumab, Pentoxifylline, Phosphodiesterase 5 inhibitors, Prostacyclin analogues, Quinegolide.
The levels/effects of Hydralazine may be decreased by Amphetamines, Brigatinib, Bromperidol, Herbs (Hypertensive properties), Methylphenidate, Nonsteroidal anti-inflammatory agents, Yohimbine.
Apreszine 50: The following drugs enhance the hypotensive effects of hydralazine: Other antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, vasodilators*); Anaesthetics; Tricyclic antidepressants; Major tranquillisers; Nitrates or drugs exerting central depressant actions (including alcohol).
*Administration of Hydralazine within an hour or two of diazoxide may give rise to marked hypotension.
The following drugs antagonise the effects of hydralazine: Non-steroidal anti-inflammatory agents (especially indometacin); Corticosteroids; Carbenoxolone; Oestrogens and combined oral contraceptives.
Concurrent administration of hydralazine and beta-blockers which are subject to significant first-pass metabolism (e.g. propranolol) may result in increased bioavailability of the beta-blocker. Dosage reduction of the beta-blocker may be necessary in such cases.
MAOI's should be used with caution in patients receiving hydralazine.