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Apreszine 25: Adult: Initial dosage: 25 mg 2 times daily for the first 2-4 days; increase to 25 mg 4 times daily for balance of the first week.
Dosage titration: 50 mg 4 times daily from the second week on.
Maintenance dosage: Adjust dosage to the lowest effective levels. Up to 300 mg/day may be required in resistant patients.
Mode of Administration: Administered without regard to meals. However, food enhances bioavailability; administer consistently with regard to meals.
Apreszine 50: Posology: The dosage should be adjusted to the individual requirements of the patient. Treatment should commence with low doses which, depending on the patient's response, should be increased stepwise to achieve optimal therapeutic effect, whilst minimising unwanted effects.
Adults: Hypertension: The initial dose is 25 mg twice daily. This may be increased gradually to a maximum dose of 200 mg daily. The patient's acetylator status must be checked prior to increasing the daily dose beyond 100 mg.
Chronic congestive heart failure: Doses vary greatly between individual patients and are generally higher than those used to treat hypertension. Treatment should be initiated in hospital where the patient's individual haemodynamic values can be determined with the help of invasive monitoring. Treatment should continue in hospital until the patient has been established on the required maintenance dose. After progressive titration (initially 25 mg three or four times daily, increasing every second day) maintenance dosage averages 50-75 mg four times daily.
Children: Hydralazine is not recommended.
Elderly: There is no special dosage requirement. Systemic clearance and blood concentration of hydralazine are not affected by advanced age, though renal elimination may be affected due to diminished kidney function with age. The elderly may also be more sensitive to the hypotensive effects of hydralazine.
Method of administration: For oral administration only. Swallow the tablets with a glass of water.
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