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A review of the use of anti-fungal drugs in pregnancy concluded that parenteral Amphotericin B was the drug of first choice in the treatment of serious fungal infections in pregnancy.
Amphotericin B for Injection has been used successfully to treat systemic fungal infections in pregnant women with no obvious effects on the foetus, but only a small number of cases have been studied. Reproductive toxicity studies of Amphotericin B in rats and rabbits have been reported to show no evidence of embryotoxicity, foetoxicity or teratogenicity.
It is not known whether Amphotericin B is found in milk of nursing mothers. It is prudent to advise a nursing motherto discontinue nursing.
