The adverse effects related to the intravenous administration of Amphotericin B include nephrotoxicity, anemia, infusion related adverse events and phlebitis. Nephrotoxicity is major dose limiting organ toxicity. One manifestation is tubular necrosis. Signs of nephrotoxicity include elevated serum creatinine and blood urea nitrogen, hypokalemia and hypomagnesemia. Amphotericin B nephrotoxicity tends to be reversible, although there is evidence that doses exceeding 4 to 5 g place patients at risk for irreversible changes in renal function.