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Use in Pregnancy: Pregnancy Category C. Reproductive studies conducted in rats and rabbits have not demonstrated evidence of developmental abnormalities. However, animal reproduction studies are not always predictive of human response. There are no adequate and well-controlled studies in pregnant women.
Naproxen use during pregnancy (particularly the last trimester) is not recommended because of the known effects of NSAIDs on the fetal cardiovascular system (closure of ductus arteriosus).
Use in Lactation: Naproxen is distributed into the milk of lactating women. Naproxen use should be avoided in breastfeeding women to prevent possible adverse effects.
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