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Hypersensitivity to Naproxen Sodium, aspirin or other NSAIDs, or to any ingredient in the product.
Patients who have experienced asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactoid reactions to NSAIDs have been reported in such patients.
Patients with active or a history of peptic/gastrointestinal (GI) ulcers, chronic dyspepsia, bleeding or perforation related to previous NSAID therapy.
Patients with active or a history of recurrent peptic ulcer/hemorrhage (2 or more distinct episodes of proven ulceration or bleeding) unrelated to previous NSAID therapy.
Patients with severe renal, hepatic or cardiac failure.
During the last trimester of pregnancy.
Contraindicated in the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
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