Skelan Overdosage

Symptoms of Naproxen overdosage may include lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alterations in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, disorientation, and vomiting. Gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, and coma may also occur. Anaphylactoid reactions may also occur following an overdose. Because high levels of Naproxen Sodium may be rapidly absorbed, high and early blood levels should be anticipated. Convulsions which may or may not be drug-related have also been reported.
Manage overdosage by symptomatic and supportive care. Hemodialysis will not decrease Naproxen plasma concentration because it is highly protein-bound. Patients seen within 4 hours of ingestion may be treated with emesis and/or activated charcoal (60 to 100 g in adults, 1 to 2 g/kg body weight in children) and/or osmotic cathartic. As with hemodialysis, forced diuresis, alkalinization of urine or hemoperfusion may not be useful due to high protein binding.