
Laboratory Test Interaction: When bleeding times are determined, keep in mind that naproxen may decrease platelet aggregation and prolong bleeding time.
Naproxen may increase urinary values of 17-ketogenic steroids due to its interaction with the M-dinitrobenzene used in the assay. Discontinue naproxen therapy temporarily for 72 hours before adrenal function tests are performed if the Porter-Silber test is to be used.
Interference with urinary assays of 5-hydroxy indoleacetic acid may also be caused by naproxen.