Sinuzerc Contraindications

Loratadine is contraindicated in patients who are hypersensitive to the drug or any ingredient in its formulation. The incidence of adverse effects associated with loratadine use generally appears to be less than that associated with the use of first generation (prototypical, sedating) antihistamines, but similar effects have been reported, and the potential for typical adverse effects induced by these agents should be considered during loratadine therapy. Pharmacologic studies indicate that loratadine does not have appreciable anticholinergic effects at doses exceeding those required for antihistaminic activity, and anticholinergic-like effects (e.g., dryness of the nose) either did not occur, or occurred with a frequency similar to placebo, in clinical studies. If the fixed-combination preparation containing loratadine and pseudoephedrine hydrochloride is used, the precautions and contraindications associated with pseudoephedrine must be considered.