Evaluate renal function prior to initiation of therapy. Patients w/ hepatic impairment or renal insufficiency (eg, glomerular filtration <30 mL/min) including geriatric patients should be given a lower initial dose. Fixed combinations of loratadine & pseudoephedrine should not be used in patients w/ hepatic insufficiency while a lower initial dose should be received in those w/ renal insufficiency.
Increased plasma conc w/ ketoconazole, erythromycin, clarithromycin or cimetidine. Fixed combination of loratadine & pseudoephedrine is contraindicated w/ MAOIs as pressor effects may be potentiated.