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Antihistamine.
Pharmacology: Mechanism of Action: Loratadine is a long-acting antihistamine. It has been characterized as a specific, selective peripheral H1-receptor antagonist and has been referred to as a relatively "non-sedating" or second-generation antihistamine.
Loratadine diminishes or abolishes the major actions of histamine in the body by competitive, reversible blockade of histamine H1-receptor sites on tissues; it does not inactivate histamine or prevent its synthesis, nor, in most cases, its release. Histamine H1-receptors are responsible for vasodilatation, increased capillary permeability, flare and itch reactions in the skin, and to some extent for contraction of smooth muscle in the bronchi and gastrointestinal tract.
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